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No consistent effects of prenatal or neonatal exposure to Spanish flu on late-life mortality in 24 developed countries

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Article and its Citations
 

Alan Cohen
John Tillinghast
Vladimir Canudas-Romo

 
VOLUME 22 - ARTICLE 20
PAGES 579 - 634
Date Received: 14 Mar 2009
Date Published: 13 Apr 2010

http://www.demographic-research.org/volumes/vol22/20/

doi:10.4054/DemRes.2010.22.20
   
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Abstract

We test the effects of early life exposure to disease on later health by looking for differences in late-life mortality in cohorts born around the 1918-1919 flu pandemic using data from the Human Mortality Database for 24 countries. After controlling for age, period, and sex effects, residual mortality rates did not differ systematically for flu cohorts relative to surrounding cohorts. We calculate at most a 20-day reduction in life expectancy for flu cohorts; likely values are much smaller. Estimates of influenza incidence during the pandemic suggest that exposure was high enough for this to be a robust negative result.

Author's affiliation
Alan Cohen
Groupe de Recherche PRIMUS, Universite de Sherbrooke, Canada
John Tillinghast
Johns Hopkins University, United States of America
Vladimir Canudas-Romo
Johns Hopkins University, United States of America

Keywords
Barker hypothesis, fetal origins, Human Mortality Database, influenza, mortality, Spanish Influenza 1918-19

Word count (Main text)
5906

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